A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript profiles, and tissue function, without erasing cellular identity, a process that requires active DNA demethylation. To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, we developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay. We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.
This is basically what's thought to have happened with proto-Earth and Theia in one of the main Moon-creation hypotheses.
Main planet forms, creating a gravity well. Smaller clump forms at a Lagrange point of that gravity well. Then it gathers too much material or something else causes a destabilisation of the Lagrange point, causing the smaller, possibly now well-formed clump, to fall towards the Lagrange centre, i.e. the main planet.
In Earth's case, the clump was Theia and the resulting collision exchanged material and ultimately spat out the Earth and the Moon.
Maybe the same will happen in this burgeoning system, but we might be waiting a while to see.
It's at the L5 point and currently forming, I don't know if it's possible but I really hope they can guess at the likely end mass of each proto planet in the system.
Will this planet exceed the mass ratio for stability at L5? What happens to the the orbits when the two gas giants form?
Also a plot on Altered Carbon. “Meths”, short for methuselahs, rule the world. You get a new body if you can afford it otherwise you get what we give you.
It’s a strange title but the idea makes sense: when solar winds die down a planet with a magnetic core sees a dramatic increase in its magnetosphere. Pretty cool finding and a good reason for more extraterrestrial satellites.
This is a really interesting point; I tried flipping it on its head and the reasoning became even more obvious:
My thought was: “surely we can take advantage of relativistic effects to keep time at a slower pace locally but have it take a short enough time in the referent timeframe.” But in this case, there is a very obvious floor we’re working with: absolute zero. Because making things go relatively faster means making the other things go comparatively slower, and 0 is as slow as you can go. If subatomic particles have no movement, there’s nothing to measure, literally.
As a result, there is a very specific bound on timekeeping measurements no matter how you try to finesse things, with the amount of energy required to make minor improvements ramping up exponentially as that floor is approached.
In order to get around this, we’d have to come up with a different way to do error correction and results measurement, and I’m not sure there is one.
Summary: Measuring time is important when measuring a large number of quantum bits, and so there’s a constant race toward precision timekeeping. The article ends saying that component quality is more of a factor than the measurement of time (for now), but in the future potential advancements in quantum computing might be able to “buy time” in this arena and reduce errors in some future advancement.
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