sciencealert.com

bunkyprewster, to news in Harvard Scientist Says He's Found a Cocktail That Can Reverse Aging in Human Cells

Abstract

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript profiles, and tissue function, without erasing cellular identity, a process that requires active DNA demethylation. To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, we developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay. We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.

www.aging-us.com/article/204896/text

palordrolap, to space in We Just Got The First Evidence of Two Planets Sharing The Same Orbit

This is basically what's thought to have happened with proto-Earth and Theia in one of the main Moon-creation hypotheses.

Main planet forms, creating a gravity well. Smaller clump forms at a Lagrange point of that gravity well. Then it gathers too much material or something else causes a destabilisation of the Lagrange point, causing the smaller, possibly now well-formed clump, to fall towards the Lagrange centre, i.e. the main planet.

In Earth's case, the clump was Theia and the resulting collision exchanged material and ultimately spat out the Earth and the Moon.

Maybe the same will happen in this burgeoning system, but we might be waiting a while to see.

stevecrox,
@stevecrox@kbin.social avatar

It's at the L5 point and currently forming, I don't know if it's possible but I really hope they can guess at the likely end mass of each proto planet in the system.

Will this planet exceed the mass ratio for stability at L5? What happens to the the orbits when the two gas giants form?

There are so many cool questions

ptz, to news in Harvard Scientist Says He's Found a Cocktail That Can Reverse Aging in Human Cells
@ptz@dubvee.org avatar

I look forward to having a class of rich people who will never die with the rest of us being considered expendable /s

flipht,

Literally a sub plot of the red mars series.

teft,

Also a plot on Altered Carbon. “Meths”, short for methuselahs, rule the world. You get a new body if you can afford it otherwise you get what we give you.

Flexaris,

Great, they’ll live to see the consequences of climate change and slowly die anyway

massive_bereavement,
@massive_bereavement@kbin.social avatar

They will move to subterranean refuges and keep their everlasting bodies connected to the metaverse.

lozunn,

So... this is what hell was referring to all along?

  • evil people: check
  • underground: check
  • everlasting: check
  • metaverse torment: check
massive_bereavement,
@massive_bereavement@kbin.social avatar

I mean, if I had to spend some hundred years in that fun-less wii loby controlled by the Zuck...

Which is a great plot for Black Mirror. Netflix, call me.

Generic_Handel,

Remember not aging doesn't necessarily mean immortal.

https://www.wikihow.com/Build-a-Gallows

Pisodeuorrior,

Oh yes, I really look forward to a future where people like Trump or Rupert Murdock live forever.

shootwhatsmyname, to astronomy in Man Uses Strange Rock as Doorstop For Decades. It Was Worth a Fortune.
@shootwhatsmyname@lemm.ee avatar

The price tag? $75,000.

Not too bad for an old doorstop.

ChicoSuave, to astronomy in A 'Void' Hurtling Through The Solar System Blew Up Mars' Atmosphere

It’s a strange title but the idea makes sense: when solar winds die down a planet with a magnetic core sees a dramatic increase in its magnetosphere. Pretty cool finding and a good reason for more extraterrestrial satellites.

adespoton, to technology in Physicists May Have Found a Hard Limit on The Performance of Large Quantum Computers

This is a really interesting point; I tried flipping it on its head and the reasoning became even more obvious:

My thought was: “surely we can take advantage of relativistic effects to keep time at a slower pace locally but have it take a short enough time in the referent timeframe.” But in this case, there is a very obvious floor we’re working with: absolute zero. Because making things go relatively faster means making the other things go comparatively slower, and 0 is as slow as you can go. If subatomic particles have no movement, there’s nothing to measure, literally.

As a result, there is a very specific bound on timekeeping measurements no matter how you try to finesse things, with the amount of energy required to make minor improvements ramping up exponentially as that floor is approached.

In order to get around this, we’d have to come up with a different way to do error correction and results measurement, and I’m not sure there is one.

em2, to biodiversity in First Sighting: Pregnant Megamouth Shark Washes Up in The Philippines
@em2@lemmy.ml avatar

I wonder if it beached due to the 5.9 earthquake they had the other day.

HumbleHobo, to tech in Physicists May Have Found a Hard Limit on The Performance of Large Quantum Computers
@HumbleHobo@beehaw.org avatar

Summary: Measuring time is important when measuring a large number of quantum bits, and so there’s a constant race toward precision timekeeping. The article ends saying that component quality is more of a factor than the measurement of time (for now), but in the future potential advancements in quantum computing might be able to “buy time” in this arena and reduce errors in some future advancement.

aodhsishaj, to technology in Physicists May Have Found a Hard Limit on The Performance of Large Quantum Computers

TL: DR Planck time is hard.

kalkulat, to astronomy in Astronomers Spot a Disk Orbiting a Star in Another Galaxy For The First Time Ever
@kalkulat@lemmy.world avatar

Aw shucks, for ‘disc’ I read ‘planet’. And ‘Large Magellanic Cloud’ is a close neighbor. But hey, it’s a start.

Ghyste, to astronomy in Astronomers Spot a Disk Orbiting a Star in Another Galaxy For The First Time Ever

Discworld is real! Need better resolution to see Atuin and the elephants.

smuuthbrane, to astronomy in Astronomers Spot a Disk Orbiting a Star in Another Galaxy For The First Time Ever
@smuuthbrane@sh.itjust.works avatar

Tease, had me thinking they’d found a Type II civilization.

TubeTalkerX, to astronomy in China's Mars Lander Detects Subsurface Geometrical Shapes in Scientific First

Start the Reactor Quaid….

DavidGarcia, to astronomy in China's Mars Lander Detects Subsurface Geometrical Shapes in Scientific First

isn’t any shape a geometrical shape? title could have been “China’s Mars Lander Detects Subsurface Thingy”

AstridWipenaugh, to astronomy in China's Mars Lander Detects Subsurface Geometrical Shapes in Scientific First

saying they identified irregular polygonal wedges located at a depth of about 35 meters all along the robot’s journey.

So like a spaceship graveyard from the Great Star War of 4990 BC?

DigitalTraveler42,

More like cave systems or even continental outlines most likely.

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