Not my favourite but the most important: A proper fully integrated clinical information system. Currently all OSS are lacking behind seriously and especially the developing world but also rich countries would benefit so much from a proper system. But sadly even that amount wouldn’t cut it.
This is a topic that really needs money to safe lifes and safe money for everyone.
I recently donated to immich. That project created a product that allows me to take back ownership over my photographs and no longer am I dependent on Google for my memories.
A lot of the options listed in this thread are good choices - but most are big projects that get a fair amount of financial attention as it is (though very rarely enough to actually support the devs).
If I had $5k to donate to a project, I’d choose some of the really small FOSS projects that I use heavily, like AudiobookShelf
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