Yes, they are inherent issues. You can’t control who goes on that bus and therefore can’t guarantee the safety of passengers. You can’t control whether buses break down or if the routes will change or not, so you can’t guarantee riders will get to work on time, if at all. And in many cities, bus service is so poor that jobs will not hire people who ride the bus for those reasons.
You also can’t stop people from spreading bedbugs and disease, and we all saw how well you reacted to that during covid.
Accept that you’re just wrong on this. No matter how much you want buses to be a viable solution, they just aren’t.