It really depends on what software you have installed. Quite a few packages require Python to function, and removing it will prevent/affect their functioning. This is one of the main advantages of Arch though: you start with a bare-bones system, and build from there as you need. One question though, why do you need to uninstall Python?
Arch. I’ve been running it on my laptop for the last 3 years, and I’ve only switched my gaming PC from Windows in the last couple of months. Really impressed with how much Proton has improved since the Steam Deck has come out.
Moved from Ubuntu as I was having issues with the WiFi drivers on my laptop, and both my systems have been rock solid ever since.