@neuroscience Oh, and the first thing that pops up in my search is a Wikipedia quote mentioning that it's involved in physiological responses to stress and panic -- immediately tying in another broad category of symptoms I experience, being diagnosed with #GeneralizedAnxietyDisorder.
Jointly lead with Roman Pogodin, they develop a theory of how a cost function attached to weight changes during learning creates weight distributions observed in biology. Work done in @tyrell_turing group!
@tyrell_turing@Neurograce@achterbrain@neuroscience@CogCompNeuro this is where Jonny pipes in to say that voltage change at the soma doesn’t capture the full effect of a presynaptic spike on the dendritic tree, and also something about short term plasticity, and lab meeting devolves into chaos
There’s also Holler et al. 2021 from Kevan Martin’s lab:
“we combine slice electrophysiology of synaptically connected pyramidal neurons in the mouse somatosensory cortex with correlated light microscopy and high-resolution electron microscopy of all putative synaptic contacts between the recorded neurons. We find a linear relationship between synapse size and strength, providing the missing link in assigning physiological weights to synapses reconstructed from electron microscopy. Quantal analysis also reveals that synapses contain at least 2.7 neurotransmitter-release sites on average. This challenges existing release models and provides further evidence that neocortical synapses operate with multivesicular release–, suggesting that they are more complex computational devices than thought” https://www.nature.com/articles/s41586-020-03134-2
Two years ago, Dan Akarca & I wondered: Could the various features we observe in brains across species be caused by shared functional, structural & energetic constraints? 🧠⚡️
With our now published spatially embedded RNNs we show this is true!
At #CCN23 , Jonathan Cornford presented a super cool new #preprint :
Synaptic Weight Distributions Depend on the Geometry of Plasticity
arxiv.org/abs/2305.19394
Jointly lead with Roman Pogodin, they develop a theory of how a cost function attached to weight changes during learning creates weight distributions observed in biology. Work done in @tyrell_turing group!
Across two cohorts of medical students and emergency nurses, we found that healthcare experience affects neural processes in Anterior #Insula coding specifically for one's own and others' #pain