albertcardona,
@albertcardona@mathstodon.xyz avatar

@tyrell_turing @Neurograce @achterbrain @neuroscience @CogCompNeuro

There’s also Holler et al. 2021 from Kevan Martin’s lab:

“we combine slice electrophysiology of synaptically connected pyramidal neurons in the mouse somatosensory cortex with correlated light microscopy and high-resolution electron microscopy of all putative synaptic contacts between the recorded neurons. We find a linear relationship between synapse size and strength, providing the missing link in assigning physiological weights to synapses reconstructed from electron microscopy. Quantal analysis also reveals that synapses contain at least 2.7 neurotransmitter-release sites on average. This challenges existing release models and provides further evidence that neocortical synapses operate with multivesicular release–, suggesting that they are more complex computational devices than thought”
https://www.nature.com/articles/s41586-020-03134-2

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