I use Edge daily for work. Everything it Office 365 and there is of course no Outlook client or Word or whatever on Linux. So I use the web version for everything. So I might as well have Edge to do the Microsoft since surely MS must make sure their stuff works on their own browser, right? (right??).
I also use the PWA version of Teams since the native client doesn’t really work well and since somewhat recently is also “officially” unsupported.
Anyway, it keeps the MS stuff separate from my normal browsing with Firefox and I’ve disabled JavaScript in Edge for all non-MS stuff. It works pretty well. Took me some battles to get rid of the Bing sidebar but they finally made that an option you can set.