When you play with a controller, the UI is completely different. Menus are simpler; you control your character movement with the left stick, camera rotation and zoom (from third person, perspective and tactical view) with the right stick; you don't have a hotbar with your skills, instead you access everything with the shoulder buttons that open a radial menu; you can use the dpad to change what your target is (enemies, items, world clutter).
In general, you can play the game without any problems with a controller.