Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have developed
There are immunotherapy treatments for cancer already. Infections and cancer use the immune system the correct way: “tag” the problem cell/virus part with an antibody, make a lot more antibody and flood your body with it to clear the problem cell/virus.
This is the process a vaccine uses. The old vaccine method is to take a bunch of dead bacteria or inactivated virus and put that in your body. Your body should identify it and begin making antibodies against it. If you do get exposed to the disease, your body is full of antibodies which can immediately clear it, rather than letting the infection/cancer work for a few days without much of an immune response.
An autoimmune disease, a body “tags” its own cells. Then the immune system invades the person’s own tissue.
I have celiac disease. If I eat gluten, the enzymes I use to digest gluten become tagged. Unfortunately, humans make one gluten enzyme (TG2) that’s found everywhere in the body. A third of celiacs will have their thyroid tissue affected if they consume gluten.
One particular antibody, IgE, is known for extreme reactions to antigens. These are the ones known for the immediate and life-threatening allergies (peanuts, shellfish, bees, wheat).
This new stuff appears to be a way to tag antibodies or antigens or memory T cells (they hold the “blueprints” to make antibodies really quickly after your natural antibodies go away) and have the immune system “re-evaluate” the antigen. I’m guessing from the post above and a little of the article. I haven’t heard of this process in the body before.
Cancer itself is not autoimmune (autoimmune inflammation can make it more likely to happen, but tumors don’t form directly through autoimmune mechanisms). So the first pathway used for normal vaccination is what’s needed. The difficulty lies in knowing something in each specific cancer that would make a good antibody target. It is a person’s own cells and DNA, so a lot of care has to be taken to find an appropriate antigen. Immunotherapy treatments that exist are really specific to certain types of cancer. They have much less severe side effects than radiotherapy and chemotherapy.
I work in clinical (and preclinical) trials. And I have celiac disease. I’m hopeful but not optimistic that I’ll be able to eat pasta within the next decade.
Paqui, the maker of extremely spicy tortilla chips marketed as the “One Chip Challenge,” is voluntarily pulling the product from shelves after a woman said her teenage son died of complications from consuming a single chip....
Habanero tastes pretty great, but the heat is far too much for me. Like most people, I have to have it dialed down to enjoy the flavor.
Someone let me try their “Dumbass Hot Sauce” and it was very spicy, with a gross bitter taste to it. It’s made for people to show off in front of others. It’s not an enjoyable taste.
This seems like the latter kind of food. It’s not spicy as a result of trying to make something that tastes great, it sounds like it was made to be spicy as a marketing gimmick. It sounds like that coffee with “death” in the name that I hear taste nasty. It has added caffeine. It’s meant to have the highest amount of caffeine as a gimmick, not to taste good.
On Friday, an international Delta flight bound for sunny Barcelona was forced to U-turn back to its starting point, Atlanta, for an exceedingly rare air travel horror: a passenger had suffered diarrhea throughout the plane’s aisle so extensively that completing the flight was deemed untenable....
I sat out on a whitewater rafting trip with friends because I couldn’t be that far from a bathroom. After many years of testing other problems, I went to a GI doctor for the stomach issues. I had undiagnosed celiac disease.
Walmart used to have a ton of options for working class people that didn’t have banking options. Not sure if it’s still the case. Many US workers were full-time employed and housed and did not have a bank account. Check cashing was through Walmart.
When people in the US talk about a classist system, it’s more of the structure than the cost. There are state IDs that are inexpensive in most states, but the Motor Vehicles branch (or whatever the state calls their department) that issues the ID are frequently difficult to travel to in lower income areas. Occasionally, the branches are understaffed and information about what can be used as proof of ID isn’t communicated clearly. Combine this with the US’s poor labor laws, and it means that it’s risky for someone to take off work, spend significant time getting to a DMV branch, waiting in line a long time because of understaffing, then be told they need more proof of ID and to do it all over again.
It’s frustrating for me and I have a driver’s license and a white-collar job so I can drive myself to the DMV easily and not worry about losing my job or losing a half-day’s pay.
It’s still kind of messy also because proof of birth by birth certificate wasn’t required until relatively recently. My grandad was never issued a birth certificate. As far as the government is concerned, he didn’t exist until he joined the army. We all have to take his word on when he was born and his name. He told it to the army and had no legal proof before then. So my state establishes identification without using birth certificates, which takes more paperwork and complications.
My utility company uses Twitter, and keeps it updated with better information than they do via text message alerts. I wish they would get a mastodon account. During tornado season or ice storms, it’s nice to know if power will be back on in an hour or in three days. And once the boil water notice appeared on Twitter a couple of hours before being sent out by text.
I think, because it’s a new platform that most of us want to see succeed, everyone is far more active to ensure the communities get established. If there’s a couple of days without a post in one of the 3d printing communities I subscribe to, someone will post a random print they find useful or ask a question about a new filament to keep it active. This low stress discussion is great.
The 3d printing community on that other site ais great, but sometimes it feels like posts don’t gain traction unless it’s on a 1 cubic meter Voron that can print PEEK (translation: very expensive/unique). On the Lemmy communities, there’s more discussions on Enders and Anycubics (translation: most common budget printers).
This is my account on this instance. Jerboa search doesn’t give me a ton of communities when I’m logged into my main lemmy.zip account. And I haven’t figured out a way to load a community manually on mobile that allows me to subscribe with my .zip account, so I add subscriptions infrequently on my laptop.
New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease (scitechdaily.com)
Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have developed
Apple iPhone 15 relegated to USB 2.0 unless you buy the Pro (www.pcgamer.com)
'One Chip Challenge' pulled from shelves after mother says spicy tortilla chip contributed to her son's death (www.nbcnews.com)
Paqui, the maker of extremely spicy tortilla chips marketed as the “One Chip Challenge,” is voluntarily pulling the product from shelves after a woman said her teenage son died of complications from consuming a single chip....
Passenger on Ill-Fated Diarrhea Plane Says Flight Attendants Were Forced to Craft "Makeshift Biohazard Suits" (futurism.com)
On Friday, an international Delta flight bound for sunny Barcelona was forced to U-turn back to its starting point, Atlanta, for an exceedingly rare air travel horror: a passenger had suffered diarrhea throughout the plane’s aisle so extensively that completing the flight was deemed untenable....
Twitter/X new ID Verification - First Look (lemmy.world)
Thanks to Popcrave twitter.com/popcrave/status/1691852136236327316?s…...
Twitter is throttling traffic to websites Elon dislikes (www.washingtonpost.com)
10 days after 3rd party reddit app shutdown, Lemmy's top 10 instances combine for a thriving userbase of 234,000 (lemmy.world)
Current breakdown at the time of this post sorted by the number of monthly active users:...