The US has a long track record of supporting some of the most brutal regimes all around the world if it serves their geopolitical interests. In that way its support for Israel isn’t much of an anomaly.
More specifically though, Israel serves as a base from which the US can project military power. That prevents other states in the region from taking full advantage of their natural or geographic resources.
For example, the US wants to ensure oil is traded in US dollars. That creates demand for the dollar which inflates its value relative to other currencies. In that way, US financial capital is given an advantage over the rest of the world. This arrangement isn’t necessarily ideal for oil rich countries as it essentially means some of the value of their oil is getting siphoned off. However, the threat of military intervention may keep these states in line. However, many of them have started to experiment with trading in other currencies which might make the US uneasy.
The second thing I can think of is the US wants to ensure Egypt does not use the Suez Canal as a political weapon like it has historically. In such cases, Israel has been used as proxy through which western countries invaded Egypt to try and take back control of the canal. Since the canal remains very important trade route from which the US and its allies benefit, the US needs some sort of leverage to ensure it stays open to them.