Of course. It’s the nature of the disagreement. And unpopular opinion about random topics is just an unpopular opinion. People will see me as an idiot, ignorant, or stupid. They may think I have questionable morals or priorities. But that’s it. I’m just another stupid person on the Internet. I can have some of these disagreements with friends where I have an unpopular opinion, but depending on the severity it’s inconsequential.
With a sin though, I’ve done something that goes against God’s word and rules. If I don’t ask for forgiveness, I will be eternally punished for it. Disagreements here are disagreements on what God says, which is heresy.