Of all the design decisions in GIMP that seem to make it so weird or different to someone coming from Photoshop, Adobe has put in 2X the amount of design choices into their software simply to try to thwart piracy.
The amount of stupid libraries and processes it loads and “requires” to run is just crazy.
A lot of it became apparent when Apple dropped 64-bit support a few years back.
Developers had a decade to update everything to 64-bit. All the fancy (and expensive) Adobe apps were 64-bit, but all their licensing dependencies and anti-piracy libraries were strangely still 32-bit.
People with legit copies couldn’t run anything after upgrading macOS. Only those with cracked/pirated versions (that didn’t load the 32-bit libraries) could actually use the software.
I have no doubt that the mess of libraries and copy protection that Adobe “requires” would prevent their software from working under WINE.