With linux you don’t have drives, at least not in a sense that you’d have in Windows with C:, D:…
You absolutely can have /dev/sda as your operating system drive, /dev/sdb1 mounted on /home/nomad/Documents, /dev/sdc1 mounted on /home/nomad/Videos and so on. Or use whatever names you wish. I had this kind of setup for years before changing the whole hardware with drives big enough to hold all the data (and a NAS, but that’s another topic).
Another option is to use LVM which allows you to manage available storage space more flexible, but that will mix your data across multiple drives even if they have separate volumes (roughly equivalent to traditional partitions).
And no matter which option you choose remember to have backups (and test that they work) since all the hardware will eventually fail.