That’s the primary way I install and play GOG games. It’s easy to set up using Bottles. Galaxy used to run horribly on Wine, but it has improved recently. I help maintain the Galaxy installer in Bottles, and earlier this year we increased its grade from silver to gold, meaning all functions work with minimal glitches now.
It isn’t perfect yet, it lags for about a minute right after launch, and I’d recommend going into settings and disabling the “Cloud saves” and “Overlay” features as these can cause crashes sometimes. Other than that, everything works well and performance is good.