The immediate advantage is that you could get newer mesa in your distrobox but continue to use a stable one in the host so that it doesn’t fuck up your more important work. I switched to using containers or flatpaks for everything on my system a while ago. I have a distrobox for running odd games I get off Itch and stuff like Steam/Bottles is from flatpak. I even run Silverblue now and haven’t had any major issues for about 2 years at this point. Hell I was switching between GNOME 45 Beta and 44 Stable like it was no big deal.