It does take some adjusting- the pitfalls you’d encounter with Distrobox on Universal Blue are the same as Distrobox on any other distro, so first I’d say to try moving your workflow to Flatpak and Distrobox on your current system or a VM and see how it works out. Generally Flatpak is preferred to a rootless Distrobox which is preferred to a rootful one, but sometimes there’s not a Flatpak for something (especially command line tools) and you need access to hardware or system level stuff that only a rootful one can do properly.