Thing is, what’s the alternative? Either you put a hard limit on the inventory, or you give players an infinite inventory. The latter can be made to work, but it also takes away the element of risk.
Perhaps ‘inventory size’ could be tied with difficulty settings. If you want a Deus Ex-type experience where you really have to be picky about what you bring, maybe that should be down to the player; and so should a huge inventory that lets you bring everything everywhere.