Ohh man, you have a treasure trove of content ahead of you if you like. He played isaac daily for almost a decade, starting on the flash version.
There are literally thousands of episodes of astute, off the cuff commentary about whatever while he did runs. Markiplier even credited a guide he wrote about streaming to be a big part of why he got started.
Dude doesn’t play isaac anymore, but if you enjoy daily, mundane bullshit discussed in an entertaining way, you’ll likely enjoy his work.