Well… no. There are maybe 50 women total who could play in the NFL, mostly as kickers. In basketball, women use a smaller ball because their hands are just smaller. Someone who’s FTM is probably not going to be able to compete.
There are enduring advantages from living most of your life pumped with testosterone. But there’s so few top athletes who transition MTF in their prime, it’s not a big problem. Just look at Caitlyn Jenner. She could still beat most women (and men) at a track meet.