I’m neurodivergent, and I laugh in many instances South Park made fun of neudivergent and mentally disabled people. I’m Latin American, South Park made fun of latin americans so many times. I’m progressive, South Park made fun of progressives so many times. I’m atheist, same thing. I’m bisexual, same thing, I could go on.
The problem with the Mr Garrison episodes is that, they are so viscerally transphobic, it is very obviously made in such bad faith.
Of course they are not the worse thing depicted in South Park, but yeah, a show with the objective to be as offensive as possible gotta hit somewhere in a very personal point eventually.