I’ve been blocking Google in my DNS resolver for almost a year. Haven’t noticed any major issues. If a website doesn’t work, I open it in the Mullvad Browser while connected to a proxy server and the Mullvad adblocking DoH resolver. That way Google doesn’t get the IP I use for all other connections. I almost never have to use that though, most things work without connections to Google services. It’s not much effort, if you use NextDNS, just enable the ‘No Google’ filterlist. You can also import that list into your Pi-Hole or AdGuard Home, it’s available on GitHub: github.com/nickspaargaren/no-google. I use Piped to access YouTube, the only Google service I use. All connections to YouTube are proxied through the Piped server, so I don’t need to connect to it directly. Edit: If you use the Safing Portmaster, you can also use its built-in Google filterlist to block all connections.