I use Vortex just because so many large mods have the options more simply configurable through it than having to go and open a file and edit it manually. I’m comfortable installing mods by hand, but at the same time Fallout 4 is fucked up beyond belief with it’s built in mod management, so using Vortex is a must just to get the mods to load properly.
I preferred an older manager though. It was even more straight forward. I don’t think it was Nexus’s own, but maybe… It’s been so damn long.