I’ve had 22, 80, & 443 open for literal decades. Key auth only on ssh. 80 & 443 rev proxy to inside web services I want to expose only. Also host game servers as needed.
Keep your stuff up to date and follow best practices for securing it. Use things like crowdstrike. If you can segment your network, go ahead.
Unless you have a target on your head your main concern is going to be scripts looking for vulnerabilities.