This could be a miniseries. Each episode, Quark takes on a new human cultural challenge and interprets it through Ferengi cultural lenses. Obviously they did this on the show but I can really picture a different side of the character coming out in a completely safe setting like his own personal holosuite. Antics might be especially humorous if his instructor was someone who had a unique perspective on human culture too, as the Doc in Voyager did while trying to help 7/9.