Few drugs will do it without also having an underlying sense of safety and security present.
If you want to know what it feels like, find some 5-meo-dmt. Or smoke some nn-dmt while coming down off molly and in a safe environment.
Personally, I found ego disolution through meditation before I found it with drugs, and I had taken some very high doses. Now I can take a much smaller dose of a tryptamine and let myself sink into that sense of safety.
Once you trust in the process and assuming you’re in a safe space, you see how much it’s more about swt and setting, and less about the drug or dose.