It’s what I have.
Case choice for mini-itx is pretty limited, but it’s getting better. There are group buyins for small run manufacturing, like mechanical keyboards - but I’ve never been involved in one of those.
Not sure if there are any that would fit a 4090, tho!
But I love em!
I have a clean desk, nothing flashing, no risk of a glass side panel exploding.
The builds are a little more challenging and more expensive, but I quite enjoy it. Have to make sure parts fit, cable management has to be spot on, you need decent fans because there are less of them