My son does tmodloader via steam, but I think its native Linux. Works without issue.
I play WoW and run Trade Skill Master (in the same wine bottle prefix). I also run RaiderIO/WoW Up/CurseForge (Linux native).
I had issues with mods for The Forest and Sons of the Forest. Never got them working.
FF XIV DPS meter worked after a lot of tinkering. Had to go to a specific discord to get the info as the modders didn’t keep their READMEs in GitHub up to date. Wish that shit was searchable.