But basically, just as it has been since the dawn of PC Gaming, it’s a case by case scenario.
However!
If you are dealing with intensive, single thread tasks (AKA Emulating PS2 and higher, or video rendering), you should get a noticeble increase on performance due to the CPU being relegated of audio-related tasks.
And finally, 99.9% of PC users don’t need an output higher than 48Khz, 16-Bit. So if you aren’t the exception, put your settings around those numbers to enjoy a bit of extra performance.