I always pick up everything and salvage or sell, just so I don’t have to worry about not having enough money or mats to do upgrades later.
I get the sentiment though. In World Tier 3 at lvl 55, your loot drops start getting capped pretty heavily in terms of stats. I was pretty much getting garbage loot, even if they were sacred, and I got to a point where I was just blindly salvaging all rares and most legendaries unless they had aspects that were right for my build.