I had a ten-year-old account that had accumulated a modest amount of karma (34000?) over the years, and had no regrets editing and deleting all the posts (roughly 2700 of them).
I'd contributed in a number of niche subreddits and felt disgusted by the greed that Reddit was showing. More than anything the disgust that they would be profiting off my information was what pushed me to do the editing/deleting.
And since then, I realise I haven't really missed anything.
Caveat: I was never really bound by my karma score anyway, though, and regularly fact-checked people I knew would not listen just to "spend" my karma anyway.
ivanafterall