In Out of Eden , Paul W. Kahn offers a philosophical meditation on the problem of evil. He uses the Genesis story of the Fall as the starting point for a profound articulation of the human condition. Kahn's interpretation of Genesis leads him to inquiries into a variety of modern forms of evil, including slavery, torture, and genocide.
When I think "Genesis/Mega Drive twang" I think Fatal Rewind, a.k.a. The Killing Game Show. Maybe there's a better game that shows off that signature sound, but I'd struggle to name it. Any ideas? Maybe The Ooze?